Benfotiamine is a fat-soluble form of vitamin B1 (thiamine). Thiamine is needed for normal blood sugar metabolism via a non-oxygen-dependent metabolic pathway called the pentose phosphate pathway. The products of this pathway are needed for fatty acid, amino acid and nucleotide synthesis. Adequate levels of thiamine are especially critical to supporting healthy brain function, where cells rely on the pentose phosphate pathway for energy. Thiamine also helps encourage the body’s tissues against advanced glycation end products and oxidative stress, making maintaining optimal levels important for supporting cardiovascular and metabolic health.
Unfortunately, thiamine in most supplements (thiamine hydrochloride) is water-soluble, which makes it less available to the interior of the cell. As a fat-soluble form of thiamine, benfotiamine can easily penetrate the inside of cells. It has been shown to support thiamine levels faster and for longer than the water-soluble thiamine.
Thiamine is a cofactor for the pentose phosphate pathway enzyme, transketolase. In one study, benfotiamine effectively increased transketolase activity in cell cultures by 300%, compared with 20% for thiamine. This activation helps promote blood vessel health. Benfotiamine also supports a healthy inflammatory response in nuclear factor-kappa B (NF-kB) and encourages expression of nuclear factor erythroid 2-related factor 2 (Nrf2), which supports antioxidant activity in cells.
Benfotiamine has further been found to inhibit formation of neurofibrillary tangles and tau protein damage in brain tissue and support healthy lifespan in preclinical studies, as well as maintain endothelial cell function.
Overall, benfotiamine can support healthy glucose metabolism and promote healthy blood glucose levels in those already within normal range. Benfotiamine with Thiamine is a dietary supplement that can help maintain blood sugar levels in those already within normal range and support the health of the nerves, kidneys, eyes, blood vessels and heart.
Dosage and Use
Take one (1) capsule four times daily, or as recommended by a healthcare practitioner.
Warnings
KEEP OUT OF REACH OF CHILDREN
DO NOT EXCEED RECOMMENDED DOSE
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
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RETURNS
RETURNS AND EXCHANGES
Have an unopened product you’d like to return? Your satisfaction is our goal. We want to ensure you are satisfied with the products you receive from Simply Nutrition. We only require that you submit a return request within 30 days from receipt of items. Just contact our Customer Service gurus to initiate your return. We are available via e-mail, chat or by phone at 1-844-559-8600. Please have your order number ready.
OUR 30-DAY STRESS-FREE RETURN POLICY
100% refund will be issued on your unopened item(s) returned within 30 days.
An exchange will be made on your damaged item(s) returned within 30 days.
Refrigerated products, such as but not limited to probiotics, are non-refundable and cannot be returned.
Gift cards, coupons, promotions, free gifts etc. are non-refundable.
We only accept returns on items shipped within the United States only.
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Hold on to any damaged products, boxes, packaging, and contents you received. We may request pictures of your damages to process your refund/exchange claim. You can start a shipping claim by contacting our Customer Service gurus.
RETURN AND EXCHANGE REQUIREMENTS:
The customer must contact Simply Nutrition by e-mail, chat or phone at (844)559-8600 and request an RMA (return merchandise authorization) number before returning any merchandise.
Customer must ship the returning merchandise within 30 days from the date that the product was received.
The customer is responsible for the return shipping costs.
We will accept a single opened container of each individual product. We will accept additional returned containers of that same product as long as they are unopened.
Returns may be subject to a 15% restocking fee.
International orders are non-refundable.
Duties and taxes paid on international orders are also non-refundable.
Exceptions to the above conditions may be granted at the discretion of Simply Nutrition on a case by case basis.
Do not return products to Simply Nutrition after 60 days have passed without calling us first! Packages received without an RMA number after 60 days have passed will not be refunded. These packages will be discarded and cannot be returned to the customer!
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